The increasing complexity of human subjects research and its oversight has prompted researchers, as well as institutional review boards, to have a forum in which to discuss challenging or novel ethical issues not fully addressed by regulations. Research ethics consultation services provide such a forum. In this article, we rely on the experiences of a national Research Ethics Consultation Collaborative that collected more than 350 research ethics consultations in a repository and published 18 challenging cases with accompanying ethical commentaries to (...) highlight four contexts in which REC can be a valuable resource. REC assists: 1) investigators before and after the regulatory review; 2) investigators, IRBs, and other research administrators facing challenging and novel ethical issues; 3) IRBs and investigators with the increasing challenges of informed consent and risk/benefit analysis; and 4) in providing flexible and collaborative assistance to overcome study hurdles, mediate conflicts within a team, or directly engage with research participants. Institutions that have established, or plan to establish, REC services should work to raise the visibility of their service and engage in open communication with existing clinical ethics consult services as well as the IRB. While the IRB system remains the foundation for the ethical review of research, REC can be a valuable service for investigators, regulators, and research participants aligned with the goal of supporting ethical research. (shrink)

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

This is a “bottom-up” paper in the sense that it draws lessons in defining disciplinary categories under study from a series of empirical studies of interdisciplinarity. In particular, we are in the process of studying the interchange of research-based knowledge between Cognitive Science and Educational Research. This has posed a set of design decisions that we believe warrant consideration as others study cross-disciplinary research processes.

Background The COVID-19 pandemic forced governments, multilateral public health organisations and research institutions to undertake research quickly to inform their responses to the pandemic. Most COVID-19-related studies required swift approval, creating ethical and practical challenges for regulatory authorities and researchers. In this paper, we examine the landscape of ethics review processes in Africa during public health emergencies (PHEs). Methods We searched four electronic databases (Web of Science, PUBMED, MEDLINE Complete, and CINAHL) to identify articles describing ethics review processes during public (...) health emergencies and/or pandemics. We selected and reviewed those articles that were focused on Africa. We charted the data from the retrieved articles including the authors and year of publication, title, country and disease(s) reference, broad areas of (ethical) consideration, paper type, and approach. Results Of an initial 4536 records retrieved, we screened the titles and abstracts of 1491 articles, and identified 72 articles for full review. Nine articles were selected for inclusion. Of these nine articles, five referenced West African countries including Liberia, Guinea and Sierra Leone, and experiences linked to the Ebola virus disease. Two articles focused on South Africa and Kenya, while the other two articles discussed more general experiences and pitfalls of ethics review during PHEs in Africa more broadly. We found no articles published on ethics review processes in Africa before the 2014 Ebola outbreak, and only a few before the COVID-19 outbreak. Although guidelines on protocol review and approval processes for PHEs were more frequently discussed after the 2014 Ebola outbreak, these did not focus on Africa specifically. Conclusions There is a gap in the literature about ethics review processes and preparedness within Africa during PHEs. This paper underscores the importance of these processes to inform practices that facilitate timely, context-relevant research that adequately recognises and reinforces human dignity within the quest to advance scientific knowledge about diseases. This is important to improve fast responses to PHEs, reduce mortality and morbidity, and enhance the quality of care before, during, and after pandemics. (shrink)

Using qualitative data based on interviews with 22 married infertile couples living in western New York State, we describe the ways in which husbands and wives interact in the process of constructing their infertility. The wives experienced infertility as a cataclysmic role failure. Husbands tended to see infertility as a disconcerting event but not as a tragedy. Couples tended to see infertility as a problem for wives. Frustration and lack of communication were typical consequences of the confrontation of husbands' and (...) wives' perspectives on infertility. Interactions with medical professionals tended to reinforce these consequences. These interactions between wives, husbands, and medical professionals may lead to taking wrong directions in treatment and to ignoring treatment options. Some of the problems we describe could be lessened by adopting a model of couple-centered treatment in a setting that incorporated routine counseling. (shrink)

Food-specific inhibition training (FSIT) is a computerised task requiring response inhibition to energy-dense foods within a reaction-time game. Previous work indicates that FSIT can increase the number of healthy foods (relative to energy-dense foods) children choose, and decrease calories consumed from sweets and chocolate. Across two studies, we explored the impact of FSIT variations (e.g., different response signals, different delivery modes) on children’s food choices within a time-limited hypothetical food-choice task. In Study 1, we varied the FSIT Go/No-Go signals to (...) be emotive (happy vs. sad faces) or neutral (green vs. red signs). One-hundred-and-fifty-seven children were randomly allocated to emotive-FSIT, neutral-FSIT, or a non-food control task. Children participated in groups of 4–15. No significant FSIT effects were observed on food choices (all values ofp> 0.160). Healthy-food choices decreased over time regardless of condition (p 0.050). Healthy choices decreased over time in the control group (p= 0.001) but did not change in the two FSIT groups (bothp> 0.300) supporting previous evidence that FSIT may have a beneficial effect on children’s food choices. Ensuring that children perform FSIT with high accuracy (e.g., by using FSIT in quiet environments and avoiding group-testing) may be important for impacts on food choices though. Future research should continue to explore methods of optimising FSIT as a healthy-eating intervention for children. (shrink)

African biblical studies (ABS) focus on biblical interpretation in Africa. Although new, it has gained massive recognition among African biblical scholars as the biblical interpretation focus that best suits the peculiar challenges that face African Christians. Its emergence, of course, was reactionary to the Western approach to the interpretation of the Bible in Africa and the practice of Christianity as well, which failed to take into cognisance the peculiar needs of African Christians. In New Testament scholarship in Nigeria, ABS has (...) come to dominate biblical interpretation, being the most preferred by New Testament scholars. However, this article notices a persistent problem with regard to methodological rigour in ABS in Nigeria. This article aims to call the attention of New Testament scholars in Nigeria to methodological rigour while engaging in ABS as this is also part of the reasons breaking into mainstream New Testament scholarship has become a problem for many of these scholars. This equally leads to poor global visibility and competitiveness on the part of many Nigerian New Testament scholars. The approach to the discussion in the work is analytical and descriptive with a touch of personal observation. Contribution: This article calls attention to the need for ABS scholars in Nigeria to emphasise methodological rigour in their research. While this will lead to recognition of the works of ABS practitioners in Nigeria and beyond, this article makes a case for academic excellence which is the hallmark of good biblical scholarship. (shrink)

Philosophers have argued that stakes affect knowledge: a given amount of evidence may suffice for knowledge if the stakes are low, but not if the stakes are high. By contrast, empirical work on the influence of stakes on ordinary knowledge ascriptions has been divided along methodological lines: “evidence‐fixed” prompts rarely find stakes effects, while “evidence‐seeking” prompts consistently find them. We present a cross‐cultural study using both evidence‐fixed and evidence‐seeking prompts with a diverse sample of 17 populations in 11 countries, speaking (...) 14 languages. Our study is the first to use an evidence‐seeking prompt cross‐culturally, and includes several previously untested populations (including indigenous populations). Across cultures, we do not find evidence of a stakes effect with our evidence‐fixed prompt, but do with our evidence‐seeking prompt. We argue that the divergent results reveal a tension within folk epistemology: people's beliefs about when it is appropriate to ascribe knowledge differ significantly from their actual practice in ascribing knowledge. (shrink)

Virtue and the Moral Life brings together distinguished philosophers and theologians with younger scholars of consummate promise to produce ten essays that engage both academics and students of ethics. This collection explores the role virtues play in identifying the good life and the good society.

This critique of nine service learning projects within schools of business is designed to encourage other educational institutions to add service learning requirements into business ethics and leadership courses. It champions the role of the faculty member teaching these courses while at the same time offering constructive analysis on pedagogy, a review of curriculum issues, identification of barriers to service learning, and guidelines for teaching service learning ventures. Challenges to all faculty involved in business ethics courses are made to better (...) manage their courses and careers from a broader context outside of university settings. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article took up the first two questions. Part II will take up the second two questions. Question 3 deals with the question as to whether DSM-V should assume a conservative or assertive posture in making changes from DSM-IV. That question in turn breaks down into discussion of diagnoses that depend on, and aim toward, empirical, scientific validation, and diagnoses that are more value-laden and less amenable to scientific validation. Question 4 takes up the role of pragmatic consideration in a psychiatric nosology, whether the purely empirical considerations need to be tempered by considerations of practical consequence. As in Part 1 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Occupying a space in-between conventional scholarship and imaginative storytelling, The University in Crumbs: A Register of Things Seen and Heard is an experimental work that dramatizes the everyday life of the academy.

The aim -- The journey -- The goal -- The view -- The endless joy.

In this interview, Ruth Groff discusses how she came to be a realist, her role as a community organizer, her relationship to critical realism, and various issues arising from her published work over the years. Discussion ranges across the nature of positivism and its legacy, the concept of falsehood, realism about causal powers, mind-independent reality, the history of philosophy, and the underlying interest in ideology-critique that runs through her thinking.

Relational reasoning is a complex form of human cognition involving the evaluation of relations between mental representations of information. Prior studies have modified stimulus properties of relational reasoning problems and examined differences in difficulty between different problem types. While subsets of these stimulus properties have been addressed in separate studies, there has not been a comprehensive study, to our knowledge, which investigates all of these properties in the same set of stimuli. This investigative gap has resulted in different findings across (...) studies which vary in task design, making it challenging to determine what stimulus properties make relational reasoning—and the putative formation of mental models underlying reasoning—difficult. In this article, we present the Multidimensional Relational Reasoning Task, a task which systematically varied an array of stimulus properties within a single set of relational reasoning problems. Using a mixed-effects framework, we demonstrate that reasoning problems containing a greater number of the premises as well as multidimensional relations led to greater task difficulty. The MRRT has been made publicly available for use in future research, along with normative data regarding the relative difficulty of each problem. (shrink)

Families and clinicians approaching a child’s death in the paediatric intensive care unit (PICU) frequently encounter questions surrounding medical decision-making at the end of life (EOL), including defining what is in the child’s best interest, finding an optimal balance of benefit over harm, and sometimes addressing potential futility and moral distress. The best interest standard (BIS) is often marshalled by clinicians to help navigate these dilemmas and focuses on a clinician’s primary ethical duty to the paediatric patient. This approach does (...) not consider a clinician’s potential duty to the patient’s family. This paper argues that when a child is dying in the PICU, the physician has a duty to serve both the patient and the family, and that in some circumstances, the duty to serve the family becomes as important as that owed to the child. We detail the limitations of the BIS in paediatric EOL care and propose the relational potential standard as an additional ethical framework to guide our decisions. (shrink)

"In this book I have tried to discover what thet social creed which we have since learned to call Liberalism meant to the eighteenth-century thinkers who formulated and popularized it. If this creed is much blown upon to-day, that may be due in part to its intrinsic defects as a system of thought; in part to the inadequacy of a fighting creed made in a comparatively..." --Taken from preface.

In recent years, there has been a convergence of democratic theory and management theory regarding the importance of participation in strategic decision making. In both the public and private sectors, the goal of increasing participation has been sought as a means to: (1) enhance the wisdom and effectiveness of decision-makers in crafting policy, and (2) secure the support of key actors in an organizations environment. Reform efforts, such as reinventing government and re-engineering the corporation, often have a goal of increasing (...) participation by changing the structure of the organization. Despite the apparent enthusiasm for participation, it is not as easy to achieve as it might seem. Studies of the strategic decision-making process suggest that structural adaptations are not a particularly effective route to increase participation. In this study I examine participation in the strategic decisions of public and private organizations. A survey of 368 senior managers in public and private organizations is used to examine a model that relates participation to the decision type, the structure of the organization and the environment in which the decision is made. In doing so, I also examine the influence of internal (employees) and external (elected officials) participation in the decision processes of public and private organizations. The degree to which a decision falls under public and legal scrutiny, and the amount of “red tape” found in the organization prove to be critical factors influencing the amount of participation. (shrink)

Frequently, moreover, the essence sought for has been supposed to be nothing objective; those who have asked the question have supposed, rather, that the property in which the essence of works of art consists must somehow involve human negotiation with something. A work of art is a creation by, and a cherished object in, the life of humanity; and to suppose that the essence of such works is some property common and peculiar to them but exclusive of human interests, would (...) be as foolish as to suppose that a description of disease, in exclusively biochemical terms, with no mention of its misery and pain, could reveal the essence of such disorders. The question, "What is a work of art?" like the question, "What is a disease?" may be interpreted as asking for the essence of works of art, on the assumption that human activities are the realizations of dispositions toward them; that to each, there corresponds a prior mental readiness which when activated leads naturally into it. Thus interpreted, the question inquires after the essence of works of art; and it presupposes that in that essence will be found some posture of the mind, i.e., that if anything is a work of art, someone has a mental disposition of some kind toward it. (shrink)

The concept of Christian Philosophy is not new in the history of philosophy. However, since the mid-twentieth century the idea of Christian Philosophy gained momentum and has become an object of explicit discussion among philosophers. The historical circumstances leading to its emergence as a distinct type of philosophy are not here discussed, and the existence of Christian Philosophy with a distinct content and purpose that sets it apart from other philosophies is here presupposed. Instead, the paper focuses on the concept (...) and methods of practising Christian Philosophy with specific reference to the methodology developed by Stanisław Kamiński. The paper argues for the suitability of his method of philosophising within the context of Christian Philosophy. Kamiński proposes a unique style that is strictly philosophical but also Christian. This methodology was based on the classical theory of being which fulfils the demand for the autonomy of philosophy but in relationship to faith. Kamiński’s doctrinal standpoints in philosophy are rational, objective, and universal. But is also most friendly and compatible with the Christian faith. In this sense, one can speak of his Christian philosophy and the suitability of his methodology for the practice of Christian philosophy. (shrink)

Aquinas, says Jean Porter, gets justice right. In this book she shows that Aquinas offers us a cogent and illuminating account of justice as a personal virtue rather than a virtue of social institutions. For Aquinas, justice is more about interpersonal morality than civic or social obligations, and Porter masterfully draws out the contemporary significance of Aquinas's perspective. - back of book.

Kingsley Widmer, one of the most insightful and provocative learned critics, has long had a considerable influence on D. H. Lawrence studies. Here he elaborates the crucial argument that the erotic conversion experience and its dialectic of social negation centrally define Lawrence, thus creating his major legacies. In dialectically considering all of Lawrence’s novels and many of his essays and stories, Widmer carries the issues beyond the texts to Lawrence’s literary and ideological inheritors, including Henry Miller and Norman Mailer. (...) In addition, he imbeds Lawrence’s fictions and roles in the "dark prophecy" of affirmatively countering the Nietzschean tradition and, in a striking chapter on Lady Chatterley’s Lover explores the use of obscenity, sexual ideology, and anticlass utopianism. This is Lawrence as a major dissident culture hero with a still pertinent, drastic revisionism of human responses in a nihilistic world. It is a large and controversial critical view. (shrink)

In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further (...) questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. (shrink)

Prof. Burton Porter surveys philosophy and ethics in a clear, concise way, examines our present attitudes and values, and offers signposts for a successful life. With full, 21st century awareness, the author points to dimensions of human beings that can be realized to create a fulfilling existence.